Diisopropylamine → Diethyl 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylate

Temperature

-78 °C

A 500 mL round-bottomed flask was charged with diisopropylamine (16 mL) and tetrahydrofuran (311 mL). The solution was cooled to −78° C. under N2 and n-BuLi (2.5 M in hexanes, 44.8 mL)) was added. The reaction was stirred for 30 minutes at −78° C. and ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate (20 g) was added as a tetrahydrofuran solution (ca. 10 mL). The solution was stirred at −78° C. for 1 hour and ethyl chloroformate (9 mL) was added neat. After stirring at −78° C. for 10 minutes, the reaction was warmed to room temperature over 2 hours. The reaction was quenched with saturated aqueous NH4Cl and was diluted with diethyl ether. The layers were separated, the aqueous layer was extracted with diethyl ether and the combined organics were dried (Na2SO4), filtered and concentrated by rotary evaporation. The residue was purified by regular phase flash column chromatography (Analogix, 0-65% hexanes/ethyl acetate).

1. stirringThe solution was stirred at −78° C. for 1 hour
2. stirringAfter stirring at −78° C. for 10 minutes
3. temperaturethe reaction was warmed to room temperature over 2 hours
4. customThe reaction was quenched with saturated aqueous NH4Cl
5. additionwas diluted with diethyl ether
6. customThe layers were separated
7. extractionthe aqueous layer was extracted with diethyl ether
8. dry with materialthe combined organics were dried (Na2SO4)
9. filtrationfiltered
10. concentrationconcentrated by rotary evaporation
11. customThe residue was purified by regular phase flash column chromatography (Analogix, 0-65% hexanes/ethyl acetate)

ORD record

ord-e035fd97566e493f9544bb2eaf1951e2

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09034875B2