Bromine → Ethyl 3-bromo-4-oxocyclohexane-1-carboxylate

HRID 574976Notes

Reaction equation

HRID 574976 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.[Br:13]Br>ClCCl>[Br:13][CH:3]1[C:2](=[O:1])[CH2:7][CH2:6][CH:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4]1

Participants

4

Reactant 2

HCID 24408BromineHCID 317638Ethyl 4-oxocyclohexanecarboxylate

Product 1

HCID 12917737Ethyl 3-bromo-4-oxocyclohexane-1-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Ethyl 4-oxocyclohexanecarboxylate (3.0 g) in dichloromethane (20 mL) was treated with bromine (2.82 g) in dichloromethane (10 mL) dropwise at 0° C. The reaction mixture was stirred at room temperature for 2 hours. The solvent was removed, and the product was used without further purification.

Workup

  1. customThe solvent was removed
  2. customthe product was used without further purification

Sources & evidence

ORD record
ord-63ff7068c3de41d9800449c6eddcd6ca
Source dataset
uspto-grants-2015_05
Patent number
US09034875B2

Reaction notes

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