HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 574981Generated: November 2, 2026
Methanol → Cyclohexanecarboxylic acid, 4-(hydroxymethyl)-, methyl ester
https://huagongshe.com/reaction/574981
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Cyclohexanecarboxylic acid, 4-(hydroxymethyl)- | HCID 202819 | — |
| Product | Cyclohexanecarboxylic acid, 4-(hydroxymethyl)-, methyl ester | HCID 11073869 | — |
Reaction Steps
To a cooled (0° C.). solution of 4-(hydroxymethyl)cyclohexanecarboxylic acid (40 g) in methanol (632 mL) was added thionyl chloride (22.15 mL) dropwise via an addition funnel. The reaction was slowly warmed to room temperature, stirred for 1 hour, concentrated by rotary evaporation, and the residue was purified by regular phase flash column chromatography (Analogix, 0-100% hexanes/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09034875B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-54f5c99b5fa04171a82bfd93b27c55da |
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| Source note | uspto-grants-2015_05 |
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