HCID 117777634, compound → HCID 178497269, compound

Participants

Reaction Steps

Methyl 5-[3-{3-[(benzyloxy)carbonyl]phenyl}-4-carbamoyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-2-fluorobenzoate (1.0 g/1.64 mmol) is dissolved in 6.8 mL of concentrated sulphuric acid. The solution is stirred at ambient temperature for 30 min and then run into ice-cold water and stirred for 30 min. The precipitate obtained is filtered off, washed with water and dissolved in EtOAc/MeTHF (50/50). The solution is washed with water and with a saturated aqueous solution of NaCl, dried over sodium sulphate, filtered and concentrated to dryness. The solid is taken up with a mixture of DCM/methanol, filtered and dried under vacuum to give 0.85 g of a beige powder (yield: 85%).

Provenance & Evidence