Benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)benzoate → 3-{4-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)benzoate	HCID 72208524	—
Reactant	6-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid	HCID 117778108	—
Product	3-{4-[(benzyloxy)carbonyl]phenyl}-6-[4-fluoro-3-(methoxycarbonyl)phenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid	HCID 117777983	66%

Reaction Steps

Obtained according to the process described in Step 3.1, using benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate and 6-[4-fluoro-3-(methoxycarbonyl)phenyl]-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid [described in Step 1.7], in the form of a yellow solid (yield: 66%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09034898B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-926114ead8cf46f68e3afee4819c8fd2
Source note	uspto-grants-2015_05