Thionyl Chloride → 1451085-14-5

HRID 575034Notes

Reaction equation

HRID 575034 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]1[CH2:12][CH:6]([CH2:7]1)[C:5]2=[N:13]O.S(Cl)(Cl)=[O:16]>O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([CH:8]3[CH2:12][CH:6]([NH:13][C:5]2=[O:16])[CH2:7]3)=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 86693063HCID 86693063, compound

Product 1

HCID 866930661451085-14-5Yield 221.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
25 °C

Procedure

Into a 20-L 4-necked round-bottom flask was placed 6-Bromo-2,3-dihydro-1H-1,3-methano-naphthalen-4-one oxime (790 g, 3.13 mol, 1.00 equiv), 1,4-dioxane (7.5 L), followed by the addition of a solution of thionyl chloride (12000 g, 32.00 equiv) in 1,4-dioxane (7.5 L) dropwise with stirring at 25° C. The resulting solution was stirred at 65° C. for 6 h. This reaction was repeated for 2 more times. The resulting mixture was concentrated under vacuum, diluted with 10 L of DCM and then quenched by the addition of 8 L of water. The resulting solution was extracted with 2×10 L of dichloromethane and the organic layers were combined. The pH value of the solution was adjusted to 7 with sodium bicarbonate (sat.). The organic layer was dried over anhydrous sodium sulfated and concentrated under vacuum. The residue was diluted with 4 L of EA and stirred at reflux for 0.5 h. The solids were collected by filtration and washed with 2×500 mL, of EA. The filtrate was concentrated under vacuum. The residue was applied onto a silica gel column eluting with PE:EA (5:1-3:1). This solid was combined with the previous solids to afford 1749 g (74%) of 5-Bromo-9-aza-tricyclo[8.1.1.0[2,7]]dodeca-2,4,6-trien-8-one as an off-white solid.

Workup

  1. customInto a 20-L 4-necked round-bottom flask was placed
  2. stirringThe resulting solution was stirred at 65° C. for 6 h
  3. concentrationThe resulting mixture was concentrated under vacuum
  4. additiondiluted with 10 L of DCM
  5. customquenched by the addition of 8 L of water
  6. extractionThe resulting solution was extracted with 2×10 L of dichloromethane
  7. dry with materialThe organic layer was dried over anhydrous sodium
  8. concentrationconcentrated under vacuum
  9. additionThe residue was diluted with 4 L of EA
  10. stirringstirred
  11. temperatureat reflux for 0.5 h
  12. filtrationThe solids were collected by filtration
  13. washwashed with 2×500 mL, of EA
  14. concentrationThe filtrate was concentrated under vacuum
  15. washeluting with PE

Sources & evidence

ORD record
ord-f3886452340b4332a2088a9bc60239be
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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