Tetrabutylammonium Fluoride → HCID 178434035, compound

Participants

Reaction Steps

9-[4-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-3-(5-methyl-4H-[1,2,4]triazol-3-yl)-but-1-ynyl]-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene-2-carboxylic acid amide (120 mg, 0.2 mmol) was dissolved in THF (10 mL), TBAF (62.9 mg, 0.24 mmol) was added. The mixture was stirred at room temperature for 14 h. The mixture was purified via HPLC separation (0.1% HCOOH) to afford the titled compound (17.6 mg, 23.0%). 1H-NMR (DMSO-d6, 400 MHz): δ 114 (s, 1H), 8.45 (s, 1H), 7.77 (s, 1H), 7.51 (s, 1H), 7.29 (s, 1H), 7.11 (s, 1H), 6.98 (d, J=8.4 Hz, 1H), 5.05 (s, 1H), 4.45 (s, 4H), 3.77 (s, 2H), 2.29 (s, 3H), 1.21 (s, 3H). LCMS: [M+H]+=393.0.

Provenance & Evidence