HRID575091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58221468

未命名化合物

结构：NC(=O)c1nc2n(c1CN1CCOCC1)CCOc1ccc(Br)cc1-2

HCID86693121

10-Bromo-3-(morpholinomethyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide

C17H19BrN4O3

PRODUCTS

生成物

结构：Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(CN4CCOCC4)n2CCO3)no1

HCID86693120

9-[(R)-3-Hydroxy-3-(5-methyl-isoxazol-3-yl)-but-1-ynyl]-3-morpholin-4-ylmethyl-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene-2-carboxylic acid amide

C25H27N5O5

PROCEDURE

实验过程

Following Procedure F, 10-bromo-3-(morpholinomethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with (2R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol to give the titled compound as a colorless solid after purification by SFC. LC MS: 478.2 [M+H]+; 1H NMR (400 MHz, DMSO) δ 8.52 (d, J=1.9 Hz, 1H), 7.57 (s, 1H), 7.33 (dd, J=8.5, 2.0 Hz, 1H), 7.09 (s, 1H), 7.03 (d, J=8.5 Hz, 1H), 6.50 (s, 1H), 6.46 (s, 1H), 6.35 (s, 1H), 4.50 (br m, 4H), 3.97 (br s, 2H), 3.52 (br m, 4H), 2.40 (s, 3H), 2.39 (m, 2H), 1.80 (s, 3H).