HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 5,7-Dichloropyrido(3,4-b)pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 2,6-Dichloropyridine-3,4-diamine | HCID 10931987 | — |
| Solvent | Glyoxal | HCID 7860 | — |
| Product | 5,7-Dichloropyrido(3,4-b)pyrazine | HCID 71742827 | 83% |
Reaction Steps
A mixture of the solution of 2,6-dichloropyridine-3,4-diamine (7.85 g, 0.044 mol) in ethanol and 40% glyoxal solution in water (26 g, 0.178 mol) was refluxed overnight. It was then cooled to ambient temperature, and the precipitates were collected, washed with EtOH, and dried in vacuo to give the title compound (7.32 g, 83% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b9dfa39a33924e5292e17cc294459ad9 |
| Source note | uspto-grants-2016_09 |