HuagongsheHuagongshe Chemistry Print Report · For research reference only
10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → (+/-)-10-(4-(Azetidin-1-yl)-3-hydroxy-3-methyl-4-oxobut-1-yn-1-yl)-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693051 | — |
| Reactant | 1-(Azetidin-1-yl)-2-hydroxy-2-methylbut-3-yn-1-one | HCID 86693197 | — |
| Product | (+/-)-10-(4-(Azetidin-1-yl)-3-hydroxy-3-methyl-4-oxobut-1-yn-1-yl)-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 71715105 | 22% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 1-(azetidin-1-yl)-2-hydroxy-2-methylbut-3-yn-1-one to give the titled compound as a yellow solid (40 mg, 22%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-5dc3ca5b835f40058a422d82a8eacc0a |
| Source note | uspto-grants-2015_05 |