HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethynyl-3-hydroxy-1-methylpiperidin-2-one → (+/-)-8-Fluoro-9-((3-hydroxy-1-methyl-2-oxopiperidin-3-yl)ethynyl)-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethynyl-3-hydroxy-1-methylpiperidin-2-one | HCID 86669576 | — |
| Reactant | 9-Bromo-8-fluoro-4,5-dihydro-[1]benzoxepino[5,4-d]thiazole-2-carboxamide | HCID 86693059 | — |
| Product | (+/-)-8-Fluoro-9-((3-hydroxy-1-methyl-2-oxopiperidin-3-yl)ethynyl)-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide | HCID 86693199 | 16% |
Reaction Steps
Similar to as described in General Procedure G, 9-bromo-8-fluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide was reacted with 3-ethynyl-3-hydroxy-1-methylpiperidin-2-one (US2012/214762A1) to give the titled compound as a white solid (20 mg, 16%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-9d0d36dd2a9b48098c3522378d0cb4aa |
| Source note | uspto-grants-2015_05 |