HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → (+/-)-10-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethynyl-3-hydroxy-1-methylpyrrolidin-2-one | HCID 58221634 | — |
| Reactant | 10-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 68312883 | — |
| Product | (+/-)-10-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 71715558 | 7% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one (WO2009/158011A1) to give the titled compound as a light yellow solid (17 mg, 7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-1a66b5a200a040dfb0b580fdd84d8514 |
| Source note | uspto-grants-2015_05 |