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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 575200Generated: October 30, 2026

2-(Pyridin-2-yl)but-3-yn-2-ol → (+/-)-9-Fluoro-10-(3-hydroxy-3-(pyridin-2-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

https://huagongshe.com/reaction/575200

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Pyridin-2-yl)but-3-yn-2-olHCID 16762502—
Reactant10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 86693051—
Product(+/-)-9-Fluoro-10-(3-hydroxy-3-(pyridin-2-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 7171510630%

Reaction Steps

Similar to as described in General Procedure G 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(pyridin-2-yl)but-3-yn-2-ol to give the titled compound (80 mg, 30%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09034866B2
Source datasetuspto-grants-2015_05
ORD IDord-8e31ca5ec1fb4cdfb2b5a939d1b86879
Source noteuspto-grants-2015_05