10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → HCID 178467682, compound

HRID 575202Notes

Reaction equation

HRID 575202 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[NH:20]1[CH:24]=[N:23][C:22]([C:25]([OH:29])([C:27]#[CH:28])[CH3:26])=[N:21]1>>[F:19][C:3]1[C:2]([C:28]#[C:27][C:25]([OH:29])([C:22]2[N:23]=[CH:24][NH:20][N:21]=2)[CH3:26])=[CH:18][C:6]2[C:7]3[N:8]([CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=3)[CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 178450381HCID 178450381, compound

Product 1

HCID 178467682HCID 178467682, compoundYield 20%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(1H-1,2,4-triazol-3-yl)but-3-yn-2-ol to give the titled compound as an off-white solid (40 mg, 20%).

Sources & evidence

ORD record
ord-e91e7f6dbb6148ac8efe5b7c01a6afc6
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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