HCID 86669589, compound → HCID 71715392, compound

HRID 575206Notes

Reaction equation

HRID 575206 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[NH:20]1[CH:24]=[C:23]([C:25]([OH:29])([C:27]#[CH:28])[CH3:26])[CH:22]=[N:21]1>>[F:19][C:3]1[C:2]([C:28]#[C:27][C:25]([OH:29])([C:23]2[CH:24]=[N:20][NH:21][CH:22]=2)[CH3:26])=[CH:18][C:6]2[C:7]3[N:8]([CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=3)[CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 86669589HCID 86669589, compoundHCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

Product 1

HCID 71715392HCID 71715392, compoundYield 19%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(1H-pyrazol-4-yl)but-3-yn-2-ol to give the titled compound as an off-white solid (46.3 mg, 19%).

Sources & evidence

ORD record
ord-326c79c17e224608b9d1713b9b60cc4a
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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