HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethynyloxolan-3-ol → (+/-)-9-Fluoro-10-((3-hydroxytetrahydrofuran-3-yl)ethynyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethynyloxolan-3-ol | HCID 15699917 | — |
| Reactant | 10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693051 | — |
| Product | (+/-)-9-Fluoro-10-((3-hydroxytetrahydrofuran-3-yl)ethynyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693216 | 19% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 3-ethynyloxolan-3-ol (US2010/144757 A1, 2010) to give the titled compound as a light brown solid (41 mg, 19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-2b7a02a7a3d847ee84a2f221e062dc90 |
| Source note | uspto-grants-2015_05 |