10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → HCID 86693221, compound

HRID 575217Notes

Reaction equation

HRID 575217 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[CH3:20][N:21]1[CH:25]=[C:24]([C:26]([OH:30])([C:28]#[CH:29])[CH3:27])[N:23]=[C:22]1[CH3:31]>>[CH3:20][N:21]1[CH:25]=[C:24]([C:26]([OH:30])([CH3:27])[C:28]#[C:29][C:2]2[C:3]([F:19])=[CH:4][C:5]3[O:11][CH2:10][CH2:9][N:8]4[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]4[C:6]=3[CH:18]=2)[N:23]=[C:22]1[CH3:31]

Participants

3

Reactant 2

HCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 86693222HCID 86693222, compound

Product 1

HCID 86693221HCID 86693221, compoundYield 4%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(1,2-dimethyl-1H-imidazol-4-yl)but-3-yn-2-ol to give the titled compound as a colorless solid (5 mg, 4%).

Sources & evidence

ORD record
ord-1b2bb00deba74accb418ee42e80cb50c
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

Loading…