HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Chloropyridin-2-yl)but-3-yn-2-ol → (+/-)-10-(3-(5-Chloropyridin-2-yl)-3-hydroxybut-1-yn-1-yl)-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Chloropyridin-2-yl)but-3-yn-2-ol | HCID 86669611 | — |
| Reactant | 10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693051 | — |
| Product | (+/-)-10-(3-(5-Chloropyridin-2-yl)-3-hydroxybut-1-yn-1-yl)-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 71715336 | 28% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(5-chloropyridin-2-yl)but-3-yn-2-ol to give the titled compound as a grey solid (60 mg, 28%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-efd392e9e1ad4fec8a2dacb584665f82 |
| Source note | uspto-grants-2015_05 |