10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → HCID 71715394, compound

HRID 575220Notes

Reaction equation

HRID 575220 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[F:20][C:21]1[CH:22]=[N:23][C:24]([C:27]([OH:31])([C:29]#[CH:30])[CH3:28])=[N:25][CH:26]=1>>[F:19][C:3]1[C:2]([C:30]#[C:29][C:27]([C:24]2[N:25]=[CH:26][C:21]([F:20])=[CH:22][N:23]=2)([OH:31])[CH3:28])=[CH:18][C:6]2[C:7]3[N:8]([CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=3)[CH2:9][CH2:10][O:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 86693224HCID 86693224, compound

Product 1

HCID 71715394HCID 71715394, compoundYield 1%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(5-fluoropyrimidin-2-yl)but-3-yn-2-ol to give the titled compound as a brown solid (3.5 mg, 1%).

Sources & evidence

ORD record
ord-121c9591c39b4af7be6b4dfcbc65af53
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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