HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Fluoro-2-fluoromethyl-3-butyn-2-ol → 9-Fluoro-10-(4-fluoro-3-(fluoromethyl)-3-hydroxybut-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Fluoro-2-fluoromethyl-3-butyn-2-ol | HCID 18424428 | — |
| Reactant | 10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693051 | — |
| Product | 9-Fluoro-10-(4-fluoro-3-(fluoromethyl)-3-hydroxybut-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693227 | 18% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 1-fluoro-2-(fluoromethyl)but-3-yn-2-ol to give the titled compound as a brown solid (42 mg, 18%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-d2ac8ae34e164b2bbb80732c6c4d3d68 |
| Source note | uspto-grants-2015_05 |