10-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → HCID 86693239, compound

HRID 575230Notes

Reaction equation

HRID 575230 reaction equation
Br[C:2]1[C:3]([F:19])=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[F:20][C:21]1([F:32])[CH2:24][N:23]([C:25](=[O:31])[C:26]([OH:30])([CH3:29])[C:27]#[CH:28])[CH2:22]1>>[F:32][C:21]1([F:20])[CH2:24][N:23]([C:25](=[O:31])[C:26]([OH:30])([CH3:29])[C:27]#[C:28][C:2]2[C:3]([F:19])=[CH:4][C:5]3[O:11][CH2:10][CH2:9][N:8]4[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]4[C:6]=3[CH:18]=2)[CH2:22]1

Participants

3

Reactant 2

HCID 8669305110-Bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 86693240HCID 86693240, compound

Product 1

HCID 86693239HCID 86693239, compoundYield 5%

Procedure

Similar to as described in General Procedure G, 10-bromo-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 1-(3,3-difluoroazetidin-1-yl)-2-hydroxy-2-methylbut-3-yn-1-one to give the titled compound as an off-white solid (14 mg, 5%).

Sources & evidence

ORD record
ord-b7372bc26a414c428f73713658f6cd9b
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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