HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol → (5)-10-(3-Hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol | HCID 58221792 | — |
| Reactant | 10-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 68312883 | — |
| Product | (5)-10-(3-Hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693116 | 9% |
Reaction Steps
Similar to as described in General Procedure G, 10-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with (2S)-2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol to give the titled compound as an off-white solid (34 mg, 9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-fa7def3621c84f5c8e0fa6de25fcd54c |
| Source note | uspto-grants-2015_05 |