10-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → HCID 86693243, compound

HRID 575238Notes

Reaction equation

HRID 575238 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[CH3:19][C:20]1[O:24][C:23]([C:25]([OH:29])([C:27]#[CH:28])[CH3:26])=[N:22][N:21]=1>>[OH:29][C:25]([C:23]1[O:24][C:20]([CH3:19])=[N:21][N:22]=1)([CH3:26])[C:27]#[C:28][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 6831288310-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 86693244HCID 86693244, compound

Product 1

HCID 86693243HCID 86693243, compoundYield 10%

Procedure

Similar to as described in General Procedure G, 10-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(5-methyl-1,3,4-oxadiazol-2-yl)but-3-yn-2-ol to give the titled compound as an off-white solid (14 mg, 10%).

Sources & evidence

ORD record
ord-948bbcf41d9c4a66bf2050af78b1fe5e
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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