10-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide → HCID 86693247, compound

HRID 575240Notes

Reaction equation

HRID 575240 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1.[S:19]1[CH:23]=[N:22][N:21]=[C:20]1[C:24]([OH:28])([C:26]#[CH:27])[CH3:25]>>[OH:28][C:24]([C:20]1[S:19][CH:23]=[N:22][N:21]=1)([CH3:25])[C:26]#[C:27][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[CH:12]=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 6831288310-Bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamideHCID 86693248HCID 86693248, compound

Product 1

HCID 86693247HCID 86693247, compoundYield 2%

Procedure

Similar to as described in General Procedure G, 10-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-(1,3,4-thiadiazol-2-yl)but-3-yn-2-ol to give the titled compound as an off-white solid (1.7 mg, 2%).

Sources & evidence

ORD record
ord-6db6d688a77f4861b7e002b2183f78b8
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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