HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethynyloxolan-3-ol → (+/-)-9-(3,4-Dihydroxy-3-methyl-but-1-ynyl)-8-fluoro-4,5-dihydro-6-oxa-3-thia-1-aza-benzo azulene-2-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethynyloxolan-3-ol | HCID 15699917 | — |
| Reactant | 9-Bromo-8-fluoro-4,5-dihydro-[1]benzoxepino[5,4-d]thiazole-2-carboxamide | HCID 86693059 | — |
| Product | (+/-)-9-(3,4-Dihydroxy-3-methyl-but-1-ynyl)-8-fluoro-4,5-dihydro-6-oxa-3-thia-1-aza-benzo azulene-2-carboxylic acid amide | HCID 86693117 | 14% |
Reaction Steps
Similar to as described in General Procedure G, 9-bromo-8-fluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide was reacted with 2-methylbut-3-yne-1,2-diol (US2010/144757 A1) to give the titled compound as a brown solid (30 mg, 14%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-f5f4d8de1ecb4bec9ddb48fe361e887b |
| Source note | uspto-grants-2015_05 |