2-(Pyridin-2-yl)but-3-yn-2-ol → (+/-)-8-Fluoro-9-(3-hydroxy-3-(pyridin-2-yl)but-1-yn-1-yl)-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-(Pyridin-2-yl)but-3-yn-2-ol	HCID 16762502	—
Reactant	9-Bromo-8-fluoro-4,5-dihydro-[1]benzoxepino[5,4-d]thiazole-2-carboxamide	HCID 86693059	—
Product	(+/-)-8-Fluoro-9-(3-hydroxy-3-(pyridin-2-yl)but-1-yn-1-yl)-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide	HCID 86693118	7%

Reaction Steps

Similar to as described in General Procedure G, 9-bromo-8-fluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxamide was reacted with 2-(pyridin-2-yl)but-3-yn-2-ol to give the titled compound as a white solid (18 mg, 7%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09034866B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-a46aa360717d43d79e3eb1b2c103603c
Source note	uspto-grants-2015_05