HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Methylisoxazol-3-yl)but-3-yn-2-ol → (+/-)-9-Chloro-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Methylisoxazol-3-yl)but-3-yn-2-ol | HCID 58221759 | — |
| Reactant | 10-Bromo-9-chloro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 89755490 | — |
| Product | (+/-)-9-Chloro-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 89754598 | 32% |
Reaction Steps
Similar to as describe in General Procedure G, 10-bromo-9-chloro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with racemic 2-(5-methyl-1,2-oxazol-3-yl)but-3-yn-2-ol to give the titled compound as a yellow solid (40 mg, 32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-27724e76e6a9483b8b77ae2fb24e6483 |
| Source note | uspto-grants-2015_05 |