反应详情

Similar to as described in General Procedure G, 3-((4-acetylpiperazin-1-yl)methyl)-10-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide (prepared similarly as described in the synthesis of 10-bromo-3-(pyrrolidin-1-ylmethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide replacing pyrrolidine with 1-(piperazin-1-yl)ethanone) was reacted with 2-methylbut-3-yn-2-ol to give the titled compound as a colorless solid (34 mg, 42%).

1. customprepared similarly