Dimethylamine → 5-bromo-N,N-dimethylpyridin-2-amine

HRID 57527Notes

Reaction equation

HRID 57527 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[CH3:9][NH:10][CH3:11]>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([N:10]([CH3:11])[CH3:9])=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 693532,5-Dibromopyridine

Product 1

HCID 38030415-bromo-N,N-dimethylpyridin-2-amine

Procedure

A solution of 2,5-dibromopyridine (10 g, 42.3 mmol) in aqueous dimethylamine (50 mL) was refluxed overnight. The volatiles were removed in vacuo, and the residue was treated with EtOAc/PE. The precipitates were collected by filtration and dried to give the title compound. MS (m/z): 201 (M+H)+, 203 (M+H)+.

Workup

  1. customThe volatiles were removed in vacuo
  2. additionthe residue was treated with EtOAc/PE
  3. filtrationThe precipitates were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-7e0f5da036cf477684042cc8d8c4bf58
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Reaction notes

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