Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorophenol → (R)-3-((2-chlorophenoxy)methyl)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorophenol | HCID 7245 | — |
| 반응물 | (R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol | HCID 58221468 | — |
| 반응물 | 10-bromo-3((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693288 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | 10-Bromo-3-((2-chlorophenoxy)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693298 | — |
| 생성물 | (R)-3-((2-chlorophenoxy)methyl)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide | HCID 86693297 | 28% |
반응 단계
Similar to as in General Procedure E with the exceptions of using Pd(PPh3)4 in DMSO, 10-bromo-3-((2-chlorophenoxy)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide (prepared similarly to 10-bromo-3-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide replacing 2-methylbenzimidazole with 2-chlorophenol) was reacted with (R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol to give the titled compound as a colorless solid (39 mg, 28%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09034866B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-24bb4483289b4c1abe1095909d75ae60 |
| 출처 메모 | uspto-grants-2015_05 |