2-Methyl-3-butyn-2-ol → HCID 86693300, compound

HRID 575272Notes

Reaction equation

HRID 575272 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[C:12]([CH2:18][N:19]4[CH2:23][CH2:22][C:21](=[O:24])[CH2:20]4)=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:25]=1.[CH3:26][C:27]([OH:31])([C:29]#[CH:30])[CH3:28]>>[OH:31][C:27]([CH3:28])([CH3:26])[C:29]#[C:30][C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[C:12]([CH2:18][N:19]4[CH2:23][CH2:22][C:21](=[O:24])[CH2:20]4)=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:25]=1

Participants

3

Reactant 2

HCID 82582-Methyl-3-butyn-2-olHCID 86693301HCID 86693301, compound

Product 1

HCID 86693300HCID 86693300, compoundYield 31%

Procedure

Similar to as described in General Procedure G, 10-bromo-3-((3-oxopyrrolidin-1-yl)methyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-methylbut-3-yn-2-ol to give the titled compound as a yellow solid (34.0 mg, 31%).

Sources & evidence

ORD record
ord-39fcc2a1c1b84d5ebc3e92d16a7fe66f
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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