HRID575280

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID201497

Morpholine, 4-(2-amino-2-methylpropyl)-

C8H18N2O

结构：Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC4CCOCC4)n2CCO3)no1

HCID86693302

未命名化合物

PRODUCTS

生成物

结构：Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)c(C(=O)NC(C)(C)CN4CCOCC4)n2CCO3)no1

HCID86693308

未命名化合物

PROCEDURE

实验过程

Prepared as described for (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide replacing 4-aminotetrahydropyran with 2-methyl-1-morpholinopropan-2-amine. Off-white solid 20 mg, 12%).

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bdadfe13bd75434395810f753aeb1914
来源数据集: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09034866B2
来源说明: uspto-grants-2015_05

反应 SMILES

[OH:1][C@:2]([C:32]1[CH:36]=[C:35]([CH3:37])[O:34][N:33]=1)([CH3:31])[C:3]#[C:4][C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH2:13][CH2:12][N:11]3[C:15]([C:21](NC4CCOCC4)=[O:22])=[C:16]([C:18]([NH2:20])=[O:19])[N:17]=[C:10]3[C:9]=2[CH:30]=1.[CH3:38][C:39]([NH2:48])([CH3:47])[CH2:40][N:41]1[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1>>[OH:1][C@:2]([C:32]1[CH:36]=[C:35]([CH3:37])[O:34][N:33]=1)([CH3:31])[C:3]#[C:4][C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH2:13][CH2:12][N:11]3[C:15]([C:21]([NH:48][C:39]([CH3:38])([CH3:47])[CH2:40][N:41]4[CH2:42][CH2:43][O:44][CH2:45][CH2:46]4)=[O:22])=[C:16]([C:18]([NH2:20])=[O:19])[N:17]=[C:10]3[C:9]=2[CH:30]=1