HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → (R)-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl) ethynyl)-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one | HCID 86693296 | — |
| Reactant | Racemic 9-bromo-4-fluoro-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide | HCID 89754787 | — |
| Product | (R)-9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl) ethynyl)-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide | HCID 89754958 | 59% |
Reaction Steps
Similar to as described in General Procedure G, racemic 9-bromo-4-fluoro-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give the titled compound as a white solid 8.9 mg (59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-8a27f8a20da240ecb4b8aba08872a577 |
| Source note | uspto-grants-2015_05 |