HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylbut-3-yne-1,2-diol → (+/-)-3-Cyclopropyl-10-(3,4-dihydroxy-3-methyl-but-1-ynyl)-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylbut-3-yne-1,2-diol | HCID 22136905 | — |
| Reactant | 10-Bromo-3-cyclopropyl-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | HCID 86693169 | — |
| Product | (+/-)-3-Cyclopropyl-10-(3,4-dihydroxy-3-methyl-but-1-ynyl)-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide | HCID 86693338 | 50% |
Reaction Steps
10-bromo-3-cyclopropyl-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with 2-methylbut-3-yne-1,2-diol via General Procedure E to yield 21 mg (50%) of (±)-3-cyclopropyl-10-(3,4-dihydroxy-3-methyl-but-1-ynyl)-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-9caae227273b444687b96fc78f479203 |
| Source note | uspto-grants-2015_05 |