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HRID575310

反应详情

EQUATION

反应方程式

HRID 575310 的结构方程式

REACTANTS

反应物

2
结构：C#C[C@@](C)(O)c1noc(C)n1
HCID86669593

未命名化合物

结构：NC(=O)c1nc2n(c1C1CC1)CCOc1cc(F)c(Br)cc1-2
HCID86693169

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc([C@](C)(O)C#Cc2cc3c(cc2F)OCCn2c-3nc(C(N)=O)c2C2CC2)no1
HCID86693342

未命名化合物

收率 14%

PROCEDURE

实验过程

10-bromo-3-cyclopropyl-9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was reacted with (R)-2-(5-methyl-1,2,4-oxadiazol-3-yl)but-3-yn-2-ol via General Procedure E to yield 8.2 mg (14%) of 3-cyclopropyl-9-fluoro-10-[(3R)-3-hydroxy-3-(5-methyl-1,2,4-oxadiazol-3-yl)but-1-ynyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide.