HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol → HCID 86693345, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol | HCID 58221468 | — |
| Reactant | HCID 86693346 | HCID 86693346 | — |
| Product | HCID 86693345 | HCID 86693345 | 46% |
Reaction Steps
10-bromo-9-fluoro-3-(trifluoromethyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was reacted with (2R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol via General Procedure E to afford 38 mg (46%) of (R)-9-fluoro-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-3-(trifluoromethyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-a1231da6e9524ec7973056dcbea2d27f |
| Source note | uspto-grants-2015_05 |