2-Methyl-3-butyn-2-ol → HCID 178459034, compound

HRID 575395Notes

Reaction equation

HRID 575395 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:11][CH2:10][CH2:9][N:8]3[C:12]([C:18]4[NH:22][N:21]=[C:20]([CH:23]5[CH2:25][CH2:24]5)[N:19]=4)=[C:13]([C:15]([NH2:17])=[O:16])[N:14]=[C:7]3[C:6]=2[CH:26]=1.[CH3:27][C:28]([OH:32])([CH3:31])[C:29]#[CH:30]>>[CH:23]1([C:20]2[N:19]=[C:18]([C:12]3[N:8]4[CH2:9][CH2:10][O:11][C:5]5[CH:4]=[CH:3][C:2]([C:30]#[C:29][C:28]([OH:32])([CH3:31])[CH3:27])=[CH:26][C:6]=5[C:7]4=[N:14][C:13]=3[C:15]([NH2:17])=[O:16])[NH:22][N:21]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 82582-Methyl-3-butyn-2-olHCID 178513779HCID 178513779, compound

Product 1

HCID 178459034HCID 178459034, compoundYield 6.6%

Procedure

3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-10-(3-hydroxy-3-methyl-but-1-ynyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide was prepared similarly to General Procedure G with slight modifications. 10-bromo-3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide was reacted with 3-methyl-1-butyne-3-ol to afford 5.5 mg (6.6% yield). M+1=419.0.

Workup

  1. customto afford 5.5 mg (6.6% yield)

Sources & evidence

ORD record
ord-25e764fc4708433b8d6e49f65ac432b3
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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