N-Iodosuccinimide → 10-Bromo-2,3-diiodo-6-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

HRID 575402Notes

Reaction equation

HRID 575402 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][CH2:13][CH2:12][N:11]3[C:7](=[N:8][C:9]([I:16])=[C:10]3[I:15])[C:6]=2[CH:17]=1.Br[C:19]1C=CC2OC(C)CN3C=CN=C3C=2C=1.IN1C(=O)CCC1=O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][CH:13]([CH3:19])[CH2:12][N:11]3[C:10]([I:15])=[C:9]([I:16])[N:8]=[C:7]3[C:6]=2[CH:17]=1

Participants

4

Reactant 3

HCID 120273N-IodosuccinimideHCID 866930489-Bromo-2,3-diiodo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azuleneHCID 8669345010-Bromo-6-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

Product 1

HCID 8669345110-Bromo-2,3-diiodo-6-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

Procedure

10-bromo-2,3-diiodo-6-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine was prepared similarly according to 9-bromo-2,3-diiodo-4,5-dihydro-6-oxa-1,3a-diaza-benzo[e]azulene. 10-bromo-6-methyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine was reacted with N-iodosuccinimide to afford 324 mg (90% yield) of a yellow solid.

Sources & evidence

ORD record
ord-4cb1693e77764566a4fe7097a7524918
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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