HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Oxan-2-yl)-1H-pyrazole-5-carbaldehyde → HCID 86693468, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Oxan-2-yl)-1H-pyrazole-5-carbaldehyde | HCID 3164313 | — |
| Reactant | Methyl 10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate | HCID 86693079 | — |
| Product | HCID 86693468 | HCID 86693468 | 43% |
Reaction Steps
Methyl 10-bromo-9-fluoro-3-(hydroxy(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate was prepared similarly according to the procedure in Example 9. Methyl 10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate was reacted with 2-tetrahydropyran-2-ylpyrazole-3-carbaldehyde to afford 329 mg (43% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-273657e64e274289b671266a624d6f23 |
| Source note | uspto-grants-2015_05 |