HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-formylazetidine-1-carboxylate → HCID 86693475, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-formylazetidine-1-carboxylate | HCID 10726182 | — |
| Reactant | Methyl 10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate | HCID 86693079 | — |
| Product | HCID 86693475 | HCID 86693475 | 63% |
Reaction Steps
Methyl 10-bromo-3-((1-(tert-butoxycarbonyl)azetidin-3-yl)(hydroxy)methyl)-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate was prepared similarly according to the procedure in Example 9. Methyl 10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxylate was reacted with 1-boc-3-azetidinecarboxaldehyde to afford 479 mg (63% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034866B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-1869116dedd54c918ca648984c0edeb2 |
| Source note | uspto-grants-2015_05 |