(R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol → HCID 86693535, compound

HRID 575469Notes

Reaction equation

HRID 575469 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[CH:11]3[CH2:12][CH:9]([CH2:10]3)[N:8]3[C:13]([CH2:19][C:20]4([CH3:24])[CH2:23][O:22][CH2:21]4)=[C:14]([C:16]([NH2:18])=[O:17])[N:15]=[C:7]3[C:6]=2[CH:25]=1.[CH3:26][C:27]1[O:31][N:30]=[C:29]([C@:32]([OH:36])([C:34]#[CH:35])[CH3:33])[CH:28]=1>>[OH:36][C@:32]([C:29]1[CH:28]=[C:27]([CH3:26])[O:31][N:30]=1)([CH3:33])[C:34]#[C:35][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]3[CH2:10][CH:9]([CH2:12]3)[N:8]3[C:13]([CH2:19][C:20]4([CH3:24])[CH2:23][O:22][CH2:21]4)=[C:14]([C:16]([NH2:18])=[O:17])[N:15]=[C:7]3[C:6]=2[CH:25]=1

Participants

3

Reactant 2

HCID 58221468(R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-olHCID 86693536HCID 86693536, compound

Product 1

HCID 86693535HCID 86693535, compound

Procedure

Similar to as described in General Procedure E, 10-bromo-3-((3-methyloxetan-3-yl)methyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was reacted with (R)-2-(5-methylisoxazol-3-yl)but-3-yn-2-ol to give the titled compound.

Sources & evidence

ORD record
ord-a7f76e1531894329853de6d6cebcadf8
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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