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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 575471Generated: October 30, 2026

2-Methyl-3-butyn-2-ol → 3-cyclopropyl-9-fluoro-10-(3-hydroxy-3-methylbut-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide

https://huagongshe.com/reaction/575471

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-3-butyn-2-olHCID 8258—
Reactant10-bromo-3-cyclopropyl-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamideHCID 86693537—
Product3-cyclopropyl-9-fluoro-10-(3-hydroxy-3-methylbut-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamideHCID 86693538—

Reaction Steps

Similar to as described in General Procedure E, 10-bromo-3-cyclopropyl-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was reacted with 2-methylbut-3-yn-2-ol to give the titled compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09034866B2
Source datasetuspto-grants-2015_05
ORD IDord-8b9d6d1bbb63435e95efe73b989d8ca0
Source noteuspto-grants-2015_05