2-Methyl-3-butyn-2-ol → HCID 86693544, compound

HRID 575476Notes

Reaction equation

HRID 575476 reaction equation
Br[C:2]1[C:3]([F:31])=[CH:4][C:5]2[CH:11]3[CH2:12][CH:9]([CH2:10]3)[N:8]3[C:13]([CH:19]4[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:20]4)=[C:14]([C:16](=[O:18])[NH2:17])[N:15]=[C:7]3[C:6]=2[CH:30]=1.[CH3:32][C:33]([OH:37])([C:35]#[CH:36])[CH3:34]>>[C:16]([C:14]1[N:15]=[C:7]2[C:6]3[CH:30]=[C:2]([C:36]#[C:35][C:33]([OH:37])([CH3:34])[CH3:32])[C:3]([F:31])=[CH:4][C:5]=3[CH:11]3[CH2:12][CH:9]([CH2:10]3)[N:8]2[C:13]=1[CH:19]1[CH2:22][N:21]([C:23]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:24])[CH2:20]1)(=[O:18])[NH2:17]

Participants

3

Reactant 2

HCID 82582-Methyl-3-butyn-2-olHCID 86693545HCID 86693545, compound

Product 1

HCID 86693544HCID 86693544, compound

Procedure

Similar to as described in General Procedure E, tert-butyl 3-(10-bromo-2-carbamoyl-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepin-3-yl)azetidine-1-carboxylate was reacted with 2-methylbut-3-yn-2-ol to give the titled compound.

Sources & evidence

ORD record
ord-f224d4280e0a4814a72952d45fa03e0c
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

Loading…