1-Ethynylcyclopentanol → HCID 86693546, compound

HRID 575477Notes

Reaction equation

[C:1]([N:4]1[CH2:7][CH:6]([C:8]2[N:12]3[CH:13]4[CH2:23][CH:15]([C:16]5[CH:21]=[CH:20][C:19](Br)=[CH:18][C:17]=5[C:11]3=[N:10][C:9]=2[C:24]([NH2:26])=[O:25])[CH2:14]4)[CH2:5]1)(=[O:3])[CH3:2].[C:27]([C:29]1([OH:34])[CH2:33][CH2:32][CH2:31][CH2:30]1)#[CH:28]>>[C:1]([N:4]1[CH2:7][CH:6]([C:8]2[N:12]3[CH:13]4[CH2:23][CH:15]([C:16]5[CH:21]=[CH:20][C:19]([C:28]#[C:27][C:29]6([OH:34])[CH2:33][CH2:32][CH2:31][CH2:30]6)=[CH:18][C:17]=5[C:11]3=[N:10][C:9]=2[C:24]([NH2:26])=[O:25])[CH2:14]4)[CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 870741-Ethynylcyclopentanol

HCID 86693547HCID 86693547, compound

Product 1

HCID 86693546HCID 86693546, compound

Procedure

Similar to as described in General Procedure E, 3-(1-acetylazetidin-3-yl)-10-bromo-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was reacted with 1-ethynylcyclopentanol to give the titled compound.

Sources & evidence

ORD record: ord-f2bb8c13898a41b1b3cf3329a4ea0c91
Source dataset: uspto-grants-2015_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09034866B2

Reaction notes

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