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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 575478Generated: October 29, 2026

(R)-2-(pyridin-2-yl)but-3-yn-2-ol → (R)-9-fluoro-10-(3-hydroxy-3-(pyridin-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide

https://huagongshe.com/reaction/575478

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-2-(pyridin-2-yl)but-3-yn-2-olHCID 42554703—
Reactant10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamideHCID 86693080—
Product(R)-9-fluoro-10-(3-hydroxy-3-(pyridin-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamideHCID 86693548—

Reaction Steps

Similar to as described in General Procedure F, reaction of 10-bromo-9-fluoro-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide with (R)-2-(pyridin-2-yl)but-3-yn-2-ol gave the titled compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09034866B2
Source datasetuspto-grants-2015_05
ORD IDord-6ab927f4731a4ff09b4acbb94344a412
Source noteuspto-grants-2015_05