(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → HCID 86693556, compound

Participants

Reaction Steps

Similar to as described in General Procedure G, ethyl 9-bromo-5H-spiro[benzo[2,3]oxepino[4,5-d]thiazole-4,2′-[1,3]dioxolane]-2-carboxylate was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give a diasteromeric mixture of (R)-ethyl 9-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)-5H-spiro[benzo[2,3]oxepino[4,5-d]thiazole-4,2′-[1,3]dioxolane]-2-carboxylate. Following aminolysis of the ethyl ester (similar to as described in General Procedure M) the titled compound was obtained after purification by prep HPLC

Provenance & Evidence