HCID 86693525, compound → HCID 86693559, compound

HRID 575486Notes

Reaction equation

HRID 575486 reaction equation
I[C:2]1[CH:20]=[CH:19][C:5]2[O:6][CH2:7][C:8]([F:18])([F:17])[C:9]3[N:10]([N:11]=[C:12]([C:14]([NH2:16])=[O:15])[CH:13]=3)[C:4]=2[CH:3]=1.[C:21]([C@:23]1([OH:29])[CH2:27][CH2:26][NH:25][C:24]1=[O:28])#[CH:22]>>[F:17][C:8]1([F:18])[CH2:7][O:6][C:5]2[CH:19]=[CH:20][C:2]([C:22]#[C:21][C@:23]3([OH:29])[CH2:27][CH2:26][NH:25][C:24]3=[O:28])=[CH:3][C:4]=2[N:10]2[N:11]=[C:12]([C:14]([NH2:16])=[O:15])[CH:13]=[C:9]12

Participants

3

Reactant 2

HCID 86693525HCID 86693525, compoundHCID 86693560HCID 86693560, compound

Product 1

HCID 86693559HCID 86693559, compound

Procedure

Similar to as described in General Procedure G, 9-iodo-4,4-difluoro-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxypyrrolidin-2-one to give a mixture of titled compound after purification by prep HPLC.

Workup

  1. customto give

Sources & evidence

ORD record
ord-adebdfbf7fb4451585fd4463b16cf44e
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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