HCID 86693521, compound → HCID 86693565, compound

HRID 575489Notes

Reaction equation

HRID 575489 reaction equation
I[C:2]1[CH:18]=[CH:17][C:5]2[O:6][CH2:7][CH2:8][C:9]3[N:10]([N:11]=[C:12]([C:14]([NH2:16])=[O:15])[CH:13]=3)[C:4]=2[CH:3]=1.[C:19]([C:21]1([OH:28])[CH2:25][CH:24]([CH3:26])[NH:23][C:22]1=[O:27])#[CH:20]>>[OH:28][C:21]1([C:19]#[C:20][C:2]2[CH:18]=[CH:17][C:5]3[O:6][CH2:7][CH2:8][C:9]4[N:10]([N:11]=[C:12]([C:14]([NH2:16])=[O:15])[CH:13]=4)[C:4]=3[CH:3]=2)[CH2:25][CH:24]([CH3:26])[NH:23][C:22]1=[O:27]

Participants

3

Reactant 2

HCID 86693521HCID 86693521, compoundHCID 86693566HCID 86693566, compound

Product 1

HCID 86693565HCID 86693565, compound

Procedure

Similar to as described in General Procedure G, 9-iodo-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with a ˜1:1 diastereomeric mixture of 3-ethynyl-3-hydroxy-5-methylpyrrolidin-2-one to give a mixture of titled compounds after purification by HPLC.

Workup

  1. customto give
  2. additiona mixture of titled compounds
  3. customafter purification by HPLC

Sources & evidence

ORD record
ord-1deaa9c834fa42b4a6c15b0fc89381a1
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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