HCID 86693521, compound → HCID 86693567, compound

HRID 575491Notes

Reaction equation

HRID 575491 reaction equation
I[C:2]1[CH:18]=[CH:17][C:5]2[O:6][CH2:7][CH2:8][C:9]3[N:10]([N:11]=[C:12]([C:14]([NH2:16])=[O:15])[CH:13]=3)[C:4]=2[CH:3]=1.[O:19]1[CH2:23][CH2:22][CH2:21][CH:20]1[C:24]([OH:28])([C:26]#[CH:27])[CH3:25]>>[OH:28][C:24]([CH:20]1[CH2:21][CH2:22][CH2:23][O:19]1)([CH3:25])[C:26]#[C:27][C:2]1[CH:18]=[CH:17][C:5]2[O:6][CH2:7][CH2:8][C:9]3[N:10]([N:11]=[C:12]([C:14]([NH2:16])=[O:15])[CH:13]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 86693521HCID 86693521, compoundHCID 86693568HCID 86693568, compound

Product 1

HCID 86693567HCID 86693567, compound

Procedure

Similar to as described in General Procedure G, 9-iodo-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with 2-(tetrahydrofuran-2-yl)but-3-yn-2-ol to give a mixture of titled compounds after purification by HPLC.

Workup

  1. customto give
  2. additiona mixture of titled compounds
  3. customafter purification by HPLC

Sources & evidence

ORD record
ord-63212896854549b1bee21bcf5dfd20f9
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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