(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one → HCID 86693569, compound

HRID 575492Notes

Reaction equation

HRID 575492 reaction equation
[F:1][C:2]1([F:24])[CH2:8][O:7][C:6]2[CH:9]=[CH:10][C:11](I)=[CH:12][C:5]=2[N:4]2[N:14]=[C:15]([C:21]([NH2:23])=[O:22])[C:16]([C:17]([F:20])([F:19])[F:18])=[C:3]12.[C:25]([C@:27]1([OH:34])[CH2:31][CH2:30][N:29]([CH3:32])[C:28]1=[O:33])#[CH:26]>>[F:1][C:2]1([F:24])[CH2:8][O:7][C:6]2[CH:9]=[CH:10][C:11]([C:26]#[C:25][C@:27]3([OH:34])[CH2:31][CH2:30][N:29]([CH3:32])[C:28]3=[O:33])=[CH:12][C:5]=2[N:4]2[N:14]=[C:15]([C:21]([NH2:23])=[O:22])[C:16]([C:17]([F:20])([F:19])[F:18])=[C:3]12

Participants

3

Reactant 2

HCID 86693296(R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-oneHCID 86693570HCID 86693570, compound

Product 1

HCID 86693569HCID 86693569, compound

Procedure

Similar to as described in General Procedure G, 4,4-difluoro-9-iodo-3-(trifluoromethyl)-4,5-dihydrobenzo[b]pyrazolo[1,5-d][1,4]oxazepine-2-carboxamide was reacted with (R)-3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one to give a titled compound after purification by HPLC.

Sources & evidence

ORD record
ord-389c1c042b894da79b635e87f8929ab0
Source dataset
uspto-grants-2015_05
Patent number
US09034866B2

Reaction notes

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